Scientific Staff Profiles

This page allows you to read information about people engaged in research at CAMH. You can search for researchers using the name or keyword search engine below.

Dr. John B. Vincent Molecular Neuropsychiatry and Development Laboratory Centre for Addiction and Mental Health 250 College Street, R601/602 Toronto, Ontario M5S 2S1  (416) 535-8501 ext. 6487 john_vincent@camh.net Dr. John Vincent is a Scientist and Head of the Molecular Neuropsychiatry and Development Laboratory of the Psychiatric Neurogenetics Section in the Neuroscience Research Department and an Associate Scientist of The Centre for Applied Genomics at The Hospital for Sick Children, Toronto. He is an Assistant Professor of the Child and Family Program with the Department of Psychiatry at the University of Toronto. Search again?
Areas of Research Dr. Vincent’s research is focused on providing a better understanding of the genetics and molecular pathways involved with autism and other pervasive developmental disorders such as Rett syndrome. His work includes fine mapping of the X-chromosome and epigenetic studies in autism as well as genetic studies of bipolar disorder and analysis of unstable repeat DNA (in particular, at the location of the SCA8 gene) in schizophrenia, bipolar affective disorder and depression. Current projects and collaborations include a number of experimental approaches to determine whether one gene, or several genes, or environmental influences or a combination of these factors causes these disorders. Dr. Vincent participated in an international study, including researchers at The Hospital for Sick Children, which has identified an area on chromosome 11 where there may be a gene that elevates the risk for autism. Dr. Vincent is also embarking on a new line of research that involves identifying families with autism in Pakistan. Cousin-cousin marriages are a common occurrence in Pakistan, and in families where there are many such marriages, recessive genetic disease genes may be mapped with relative ease. Thus, if such a family has four or more individuals with autism, there may be a very good opportunity to identify the disease-causing gene.
Publications Harvey C, Menon SD, Stachowiak B, Noor A, Proctor A, Mensah AK, Mnatzakanian GN, Alfred SE, Guo R, Scherer SW, Kennedy JL, Roberts WS, Srivistava AK, Minassian BA, Vincent JB. Sequence Variants Within Exon 1 of MECP2 Occur In Females With Mental Retardation. Am J Med Genet Part B (Neuropsychiatric Genet. 2007. Advance online publication. Petek E, Green N, Schwarzbraun T, Patel M, Luo W, Nakabayashi K, Choufani S, Fang H, Windpassinger C, Stamenkovic M, Robertson MM, Aschauer HN, Gurling HMD, Kroisel PM, Wagner K, Scherer SW, Vincent JB. (2006) Molecular studies of IMMP2L and mutation screening in autism and Tourette syndrome. Mol Genet Genom. 2006;277:77-81 Feuk, L, Kalervo A, Lipsanen-Nyman M, Skaug J, Nakabayashi K, Summers A, Senman L, Roberts W, Zeesman S, Kerem B, Rivlin J, Nowaczyk, MJ, Vincent JB, Szatmari P, Hartung D, Wong V, Osborne LR, Oram Cardy J, Kere J, Scherer SW, Hannula-Jouppi K. Absence of a paternally-inherited FOXP2 gene in individuals with Developmental Verbal Dyspraxia. Am J Hum Genet. 2006;79:965-972. Vincent JB, Horike S, Choufani S, Paterson AD, Roberts W, Szatmari P, Weksberg R, Fernandez B, Scherer SW. An inversion INV (4) (p12-p15.3) associated with autism implicates the 4p GABA receptor gene cluster. J Med Genet. 2006;43:429-434. Schwarzbraun T, Windpassinger C, Ofner L, Vincent JB, Cheung J, Scherer SW, Wagner K, Kroisel PM, Petek E. Genomic analysis and re-evaluation of five 7p deletion patients with Greig cephalopolysyndactyly syndrome (GCPS) European Journal of Medical Genetics. 2005;49:338-345. Gauthier J, de Amorim G, Mnatzakanian GN, Saunders C, Vincent JB, Toupin S, Lacasse H, Kauffman D, St-Onge J, Laurent S, Macleod PM, Minassian BA, Rouleau GA. Clinical stringency greatly improves mutation detection in Rett syndrome. Can J Neurol Sci. 2005;32:321-326. Vincent JB, Melmer G, Bolton PF, Hodgkinson S, Holmes D, Curtis D, Gurling HMD. Genetic linkage analysis of the X chromosome in autism, with emphasis on the fragile X region. Psychiatr Genet. 2005 June 15:83-90. Luca VD, Vincent JB, Muller DJ, Hwang R, Shinkai T, Volavka J, Czobor P, Sheitman BB, Lindenmayer JP, Citrome L, McEvoy JP, Lieberman JA, Kennedy JL. Identification of a naturally occurring 21bp deletion in alpha2c noradrenergic receptor gene and cognitive correlates to antipsychotic treatment. Pharmacol Res. 2005;51:381-384. Schwarzbraun T, Vincent JB, Schumacher A, Geschwind DH, Oliveira J, Windpassinger C, Ofner L, Ledinegg M, Kroisel PM, Wagner K, Petek E. Cloning of TULIP1, a novel CpG-associated, brain-expressed candidate gene for 14q13-linked neurological phenotypes and its murine homologue. Genomics. 2004;84: 577-586. Schwarzbraun T, Vincent JB, Schumacher A, Geschwind DH, Oliveira J, Vincent JB, Kolozsvari D, Roberts WS, Bolton PF, Gurling HMD, Scherer SW. Mutations Screening of X-Chromosomal Neuroligin Genes: No Mutations In 196 Autism Probands. Am J Med Genet (Neuropsychiatric Genetics). 2004 Aug 15;129(1):82-4.
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