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Dr. Anh Dzung Le
Neurobiology of Alcohol Section Centre for Addiction and Mental Health 33 Russell Street Toronto, Ontario M5S 2S1 (416) 535-8501 ext. 6744 anh_le@camh.net
Dr. Anh Dzung Lê, is a Senior Scientist and Head of the Neurobiology of Alcohol Section in the Neuroscience Department. He is an Associate Professor of Pharmacology at the University of Toronto.
Dr. Lê studies biological processes involved in the initiation and maintenance of alcohol dependences using preclinical animal models. He is investigating the neurochemical mechanisms underlying the effects of stress on relapses to alcohol. Dr. Lê is examining the interaction between Corticotropin Releasing Factor (CRF) and serotonin as well as the interaction between CRF and the noradrenergic system in stress-induced relapse to alcohol and drugs. Dr. Lê is also investigating the biological bases for the co-abuse of alcohol and nicotine, particularly how nicotine might strengthen alcohol dependence as about 80 percent of alcoholics are smokers.
Publications
Shram M, Funk D, Li Z, Lê AD. Periadolescent and adult rats respond differently in tests measuring the rewarding and aversive effects of nicotine. Psychopharmacology. 2006;186(2): 201-8.
Lê AD, Li Z, Funk D, Shram M, Li TK, Shaham Y. Increased vulnerability to nicotine self-administration and relapse in alcohol-naive offspring of rats selectively bred for high alcohol intake. J Neurosci. 2006;26(6):1872-1879.
Lê, AD, Shaham Y. Neurobiology of Relapse to Alcohol. Pharmacol. Ther. 2002;94: 137-156.
Lê AD, Harding S, Juzytsch W, Fletcher PJ, Shaham Y. The role of corticotropin releasing factor in the median raphe nucleus in relapse to alcohol. J. Neurosci. 2002;22: 7844-7849.
Centre for Addiction
