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Epigenomics - Maps: Hypomethylation Chr21 & Chr22

Maps: Hypomethylation Chr 21 & 22



In the following table the methylation data from chr 21/22 tiling arrays (Schumacher et al., 2005) are available. The graphs are in a format readable by the UCSC Genome browser. The Genome Browser zooms and scrolls over chromosomes, showing the data in a seperate track next to CpG islands, CpG density, known genes and transcriptome data. By clicking on the links, the Genome browser opens automatically, displaying a specific area of chromosomes 21 or 22 (browser start position). From there, the sequence can be explored up- and downstream. The dark red graphs of the custom track on top represent the enrichment of hypo(unmethylated) DNA fragments. An example is displayed to the right. An absence of bars may represent hypermethylation of that region/CpG island.



Note: The maps are relatively large, so depending on your internet speed, loading time may take several seconds (cable), 20s-1 min (DSL) up to several minutes (56k).
Individual Chromosome Browser Start Postition
Average 8 individuals Chr 21 bp 40151646-40175349; PCP4 promoter
Average 8 individuals Chr 22 bp 18301393-18308337; TXNRD2 and COMT promoter
Individual #17 Chr 21 bp 45340709-45380709; ADARB1 promoter
Individual #17 Chr 22 bp 17836811-17850699; UFD1L promoter
Individual #18 Chr 21 bp 34000000-46976537; Chr 21 q-arm
Individual #18 Chr 22 bp 14350832-24376000; Chr 22 q-arm
Individual #19 Chr 21 bp 36981928-37029337; SIM2 promoter
Individual #19 Chr 22 bp 16930561-16958338; PEX26 promoter
Individual #21 Chr 21 bp 36672579-36719988; CHAF1B promoter
Individual #21 Chr 22 bp 20055095-20072932; RNA genes
Individual #22 Chr 21 bp 38201213-38217015; KCNJ6 promoter
Individual #22 Chr 22 bp 21170817-21190330; SUHW2 + IGLC1 promoter region
Individual #23 Chr 21 bp 44619506-44646172; TRPM2 promoter
Individual #23 Chr 22 bp 19067208-19121045; ZNF74 + SCARF2 region
Individual #24 Chr 21 bp 35165299-35200431; RUNX1 promoter
Individual #24 Chr 22 bp 19067208-19121045; SNAP29 promoter
Individual #25 Chr 21 bp 36423941-36434475; CBR3 promoter
Individual #25 Chr 22 bp 18116677-18123621; TBX1 DiGeorge region

Notes: All maps are based on the April 2003 version of the human genome draft. The April 2003 human reference sequence is based on NCBI Build 33. It has been released in conjunction with the International Human Genome Sequencing Consortium's announcement of the successful completion of the Human Genome Project.
This reference sequence covers about 99 percent of the human genome's gene-containing regions, and has been sequenced to an accuracy of 99.99 percent. The missing portions are essentially contained in less than 400 defined gaps that represent DNA regions with unusual structures that can't be reliably sequenced using current technology.

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