Genetic Marker for Anxiety Disorder

Technology ID: 002-2005

IP Type: Licensable Technology

Title: Genetic Marker for Anxiety Disorder

Inventors: Paul D. Arnold, Margaret A. Richter, James L. Kennedy

Summary:
Methods for diagnosis or susceptibility identification of patients to an anxiety or mood disorder are described. Specifically, the diagnostic method of the present invention relates to a significant association that was observed between 3 tightly linked polymorphisms lying within the same haplotype block of SLC1A1, the neuronal glutamate transporter gene, and obsessive-compulsive disorder (OCD). Furthermore, a diagnostic method of the present invention is also based on the identification of the presence of a common haplotype in the SLC1A1 gene. The strategy is contemplated for treating OCD by administering a compound that is capable of modulating expression of the SLC1A1 gene. Anxiety disorders may be the most common psychiatric illness affecting both children and adults. 19 million adult Americans suffer from anxiety disorder. OCD is a neuropsychiatric condition affecting an estimated 1 to 3% of the population worldwide. It is associated with significant morbidity and is ranked by WHO as one of the 10 most disabling conditions. Correct diagnosis will assist with early intervention that may include psycho-social treatment and antidepressant medication.

Technology Type: Diagnostic Marker / Genetic Marker

Intellectual Property: Patents filed in US and Canada

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Contact:
Klara Vichnevetski
klara_vichnevetski@camh.net
(416)595-6056

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