Compositions and Methods for Modulating Dopamine Neurotransmission

Technology ID: 001-2005

IP Type: Licensable Technology

Title: Compositions and Methods for Modulating Dopamine Neurotransmission

Inventor: Fang Liu

Summary:
The present invention provides for the diagnosis or treatment of neurological or neuropsychiatric disorders involving abnormal neurotransmission (e.g. psychostimulant addiction, depression, obesity, ADHD, narcolepsy, Parkinson’s disease, schizophrenia, Tourette’s syndrome). Methods and agents are provided for modulating dopamine transporter activity and modulating dopaminergic neurtotransmission. Although known dopaminergic stimulants (such as amphetamine, and dopamine uptake blockers etc.) can treat a variety of disorders such as ADHD, obesity and narcolepsy, the lack of neuronal selectivity of action could limit the clinical utility of the drugs. Novel agents of the present invention, which act on the brain dopamine system, have shown some behavioural properties characteristic of dopaminergic stimulant in in vivo animal models. However, these novel agents can be expected to have a more useful side effect profile in the clinic due to improved selectivity of action.

Technology Type: Diagnostic Methods / Methods of Treatment

Intellectual Property: PCT WO 2006/116874 A1 filed in May 2006

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Contact:
Klara Vichnevetski
klara_vichnevetski@camh.net
(416)595-6056

 

 

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