Pharmacogenetics

Head: Dr. Rachel Tyndale
Genetically variable drug metabolism can result in therapeutic failure and unanticipated toxicity in individuals who have variant alleles for various drug-metabolizing enzymes. In addition to the role of these enzymes in the effects of clinical drugs, this section is interested in the role that these enzymes have on drug dependence and drug-taking behaviour. Specifically, the section is investigating how genetically variable drug metabolism can alter the risk for specific drug dependencies and the amount of a drug used by dependent individuals.

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